Evidence map›Paper›PMID 40536790›Full record

ArticleACS applied bio materials2025

Self-Surfactant Poly-3hydroxybutyrate-

Sara Alfano, Lorenzo Ceparano, Benedetta Brugnoli, Gianluca Forcina, Luca Pellegrino, Francesca Cecilia Lauta, Roberto Rusconi, Iolanda Francolini, Antonella Piozzi, Andrea Martinelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara AlfanoDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.ORCID 0000-0002-8460-800X
Lorenzo CeparanoDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.
Benedetta BrugnoliDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.ORCID 0000-0002-9419-2829
Gianluca ForcinaDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.ORCID 0009-0007-3299-5339
Luca PellegrinoDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele 20072, Italy.
Francesca Cecilia LautaDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele 20072, Italy.
Roberto RusconiDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele 20072, Italy.
Iolanda FrancoliniDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.ORCID 0000-0002-0180-2334
Antonella PiozziDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.
Andrea MartinelliDepartment of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.ORCID 0000-0002-6401-9988

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyhydroxyalkanoates (PHAs) are naturally occurring polyesters with promising drug delivery applications. Their hydrophobicity enables lipophilic drug encapsulation, enhancing bioavailability but limiting colloidal stability and physiological compatibility. Surfactants crucially improve the nanoparticle dimensional stability, dispersion, wettability of hydrophobic matrices, and cellular interaction, yet conventional surfactants require additional purification and may pose physiological risks. Self-surfactant systems offer a sustainable alternative. Therefore, this research proposes a green chemical modification of PHAs to develop self-surfactant systems. Hydrophilic groups were introduced onto a poly-3-hydroxybutyrate-

Indexed as

3-Hydroxybutyric AcidAnti-Bacterial AgentsBiocompatible MaterialsCaproatesNanoparticlesSurface-Active AgentsBenzofuransDrug CarriersHumansMaterials TestingMicrobial Sensitivity TestsParticle SizePolyhydroxybutyratesStaphylococcus aureusSurface Properties3-Hydroxybutyric AcidAnti-Bacterial AgentsBenzofuransBiocompatible MaterialsCaproatesDrug Carrierspoly(3-hydroxybutyrate-co-3-hydroxyhexanoate)PolyhydroxybutyratesSurface-Active Agentsusnic acidantifoulingantimicrobialcholine taurinatemicrofluidicspolyhydroxyalkanoatessustainabilityusnic acid

Identifiers

PMID40536790
PMCPMC12284855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.