ArticleJA clinical reports2025
Anaphylaxis due to midazolam administered before induction of general anesthesia: a case report.
Article in JA clinical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pharmacovigilance and toxicological studies on safety signals associated with the combined use of propofol and midazolam.BMC anesthesiology · 2026Article
- Hypersensitivity Reactions to Benzodiazepines Used for Perioperative Premedication: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAnaphylaxis is an immediate allergic reaction. However, in some cases, there is a delay between the administration of the causative agent and the onset of anaphylaxis. CASE PRESENTATION: A 41-year-old woman was scheduled for laparoscopic myomectomy under general anesthesia combined with epidural anesthesia. Midazolam was administered, and an epidural catheter was inserted. Seven minutes after the induction of general anesthesia (17 min after midazolam administration), the patient developed tachycardia, hypotension, and redness of the face and trunk. Her hemodynamic status improved after administration of phenylephrine and elevation of both legs, and the surgery was completed. Increased blood histamine and tryptase levels were observed 30 min after the onset of hemodynamic signs. Based on the above, anaphylaxis was diagnosed. Skin tests later showed that midazolam was the causative agent.
conclusionsA case of perioperative anaphylaxis caused by midazolam, which was used before the induction of general anesthesia, was described.
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