ArticleGeroScience2026
Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein.Nutrients · 2025Review
- Replication and validation of two novel magnetoencephalography functional connectivity measures in Alzheimer's disease.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
8 authors.
Funding
Abstract
Amid the rising relevance of early and non-invasive markers for neurodegenerative diseases, such as Alzheimer's disease, this study addresses the relationship between two promising candidates: electrophysiology and plasma markers. Specifically, functional connectivity, which underlies cognitive function, with p-tau231 (i.e., a marker of incipient Aβ pathology) and neurofilament light chain (NfL, i.e., a neurodegeneration marker) were considered. Seventy-five cognitively unimpaired individuals underwent a blood extraction and two magnetoencephalography recordings, approximately 3 years apart. First, correlation analyses were conducted to examine the association between the pathology markers' concentration and FC. Subsequently, longitudinal FC changes were assessed, and their relationship with the markers' concentration was evaluated. Default mode network regions, including the middle temporal gyrus, precuneus, hippocampus, and inferior parietal lobe, presented a positive association between their alpha FC and p-tau231 positively. In contrast, NfL levels were negatively associated with theta FC in frontotemporal regions. Moreover, these areas exhibit a longitudinal theta FC decrease. Importantly, the theta FC reduction was more pronounced as NfL concentrations increased. The described alpha FC alterations do not follow a maturation trajectory and are age-independent. Thus, the alpha FC increase associated with p-tau231 levels could constitute an early electrophysiological biomarker of Aβ pathology. In contrast, the longitudinal theta FC decrease, enhanced by NfL, could constitute an early sign of neurodegeneration.
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Registered trials
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