ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
Antibacterial and cytotoxic activity of bioactives from Paenibacillus dendritiformis isolated from Lonar Soda Lake, Maharashtra, India.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundConstant research is being conducted to discover potent antibacterial and anticancer agents from natural sources like plants and microorganisms. Gram-positive Paenibacillus dendritiformis is a spore-forming bacterium with recognized industrial and economic significance in the production of important biomolecules applicable to the agricultural, pharmaceutical, and biotechnological industries.
objectivesThe objective of this study was to investigate the antibacterial and cytotoxic potential of bioactives produced by P. dendritiformis isolated from Lonar Lake sediment.
methodsP. dendritiformis was isolated from Lonar Soda Lake and characterized using colony morphology, biochemical, and phylogenetic evaluations. The process was carried out using starch casein broth (SCB), and the bioactives were characterized by LC-MS/MS. The antibacterial assay was performed by the disc diffusion assay. The cytotoxic activity was performed by employing HeLa cell culture. To understand the molecular mechanism, oxidative stress markers, pro-inflammatory markers, and apoptotic markers were evaluated.
resultsLC-MS/MS spectra reveal the presence of phytyl palmitate and phytol acetate. These bioactives from P. dendritiformis exhibit moderately significant to significant antibacterial and cytotoxic activity by substantially inhibiting the HeLa cell viability via MTT assay.
conclusionThe study demonstrates the antibacterial and cytotoxic potential of bioactive compounds from P. dendritiformis with significantly lower IC
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