ArticleEuropean journal of nuclear medicine and molecular imaging2025
Added value of multiparametric MRI for diagnosing subcentimeter functional adrenal nodules in primary aldosteronism using CXCR4-targeted PET/MRI.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The CXCR4-targeted theranostics era: a comprehensive review of a decade of progress (2015-2025).Theranostics · 2026Review
- Recent Development of CXCR4-Targeted Nuclear Medicine Research in Adrenocortical Tumors.Mini reviews in medicinal chemistry · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveThis study aims to evaluate the clinical utility of
methodsA total of 62 patients with clinical suspicion of PA were enrolled from a tertiary hospital in China. Prior to adrenalectomy, all patients underwent
resultsAmong 62 patients, 74 adrenal lesions were confirmed pathologically, comprising 37 aldosterone-producing adenomas (APA, ≥ 1 cm), 21 aldosterone-producing micronodules (micro-APA, < 1 cm), and 16 non-functioning adenomas (NFA). Key PET/MRI parameters, including SUVmax, SUVmean, LLR, OIR, and RPW, showed significant differentiation between functional adrenal nodules and normal adrenal glands (P < 0.001). For nodules ≥ 1 cm, the PET SUVmax threshold of 7.87 achieved a sensitivity of 92.3% and specificity of 95.0% for APA diagnosis. For nodules < 1 cm, the PET SUVmax threshold of 6.49 yielded a sensitivity of 68.8% and specificity of 83.3% for micro-APA diagnosis. Integrated PET/MRI significantly improved the diagnostic sensitivity for PA subcentimeter nodules from 68.8% (with PET alone) to 87.5%, and increased the area under the ROC curve from 0.760 to 0.854, with no significant reduction in diagnostic specificity.
conclusion
Indexed as
Identifiers
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Registered trials
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