Evidence map›Paper›PMID 40536538›Full record

ReviewCurrent cardiology reports2025

In-Stent Restenosis: Incidence, Mechanisms, and Treatment Options.

Michael Sola, Zachary Tugaoen, Jessica Willis, George A Stouffer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael SolaDivision of Cardiology, University of North Carolina, Chapel Hill, NC, 27599-7075, USA.
Zachary TugaoenDivision of Cardiology, University of North Carolina, Chapel Hill, NC, 27599-7075, USA.
Jessica WillisDivision of Cardiology, University of North Carolina, Chapel Hill, NC, 27599-7075, USA.
George A StoufferDivision of Cardiology, University of North Carolina, Chapel Hill, NC, 27599-7075, USA. rstouff@med.unc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo provide an overview of up-to-date treatment practices for in-stent restenosis (ISR). RECENT

findingsISR is treated with similar effectiveness by paclitaxel drug coated balloons and second-generation drug eluting stents. Sirolimus coated balloons are an emerging technology that requires further investigation. The management of ISR remains challenging even with the newest generation of drug-eluting stents. The use of intravascular imaging is highly recommended to identify the mechanisms of stent failure and to tailor the method of treatment, whether it is plain old balloon angioplasty, plaque/calcium modifying tools such as intravascular lithotripsy or rotational atherectomy, additional drug eluting stents, or drug coated balloons. Paclitaxel drug coated balloons are the most recent technological advancement which has provided an option to treat ISR that doesn't require further layers of metal. Currently, other drug coatings are being studied but it is unclear whether these balloons are as effective as paclitaxel coated balloons, with ongoing trials designed to answer this question.

Indexed as

Angioplasty, Balloon, CoronaryCoronary RestenosisDrug-Eluting StentsHumansIncidencePaclitaxelSirolimusPaclitaxelSirolimusDrug Coated BalloonsDrug Eluting Stents; BrachytherapyIn-stent RestenosisIntravascular Imaging; Target Lesion Revascularization

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.