Evidence map›Paper›PMID 40536535›Full record

Observational studyPediatric cardiology2026

Cerebral Autoregulation and Optimal Blood Pressure from Birth to Surgery in Neonates with Critical Congenital Heart Disease.

Angelica Vasquez, Eliza Gentzler, David Bateman, Diana Vargas Chaves, David Kalfa, Emile Bacha, Ganga Krishnamurthy, Nimrod Goldshtrom

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angelica VasquezDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA.
Eliza GentzlerDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA.
David BatemanDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA.
Diana Vargas ChavesDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA.
David KalfaDepartment of Surgery, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Emile BachaDepartment of Surgery, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Ganga KrishnamurthyDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA.
Nimrod GoldshtromDivision of Neonatology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, 622 West 168th St., PH 17-301, New York, NY, 10032, USA. ng2137@cumc.columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased time to surgery has been correlated with increasing cerebral fractional oxygen extraction without compensatory increase in cerebral blood flow in neonates with critical congenital heart disease (cCHD) suggesting an overwhelmed cerebral autoregulation system. Autoregulation analysis can provide precision targets such as optimal blood pressure but it remains unclear how autoregulation evolves in days preceding surgery. Our hypothesis is that longer wait times between birth and surgery are associated with increasing periods of impaired autoregulation. A retrospective observational study evaluating the time spent within optimal blood pressure (MAP

Indexed as

Blood PressureCerebrovascular CirculationHeart Defects, CongenitalHomeostasisFemaleHumansInfant, NewbornMaleRetrospective StudiesSpectroscopy, Near-InfraredCerebral autoregulationCongenital heart diseaseHemodynamicsNeonateNeurodevelopmentTiming of surgery

Identifiers

PMID40536535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.