ArticleHepatology communications2025
Resmetirom-eligible population among US adults: An estimation analysis based on NHANES 2017-March 2020.
Article in Hepatology communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- National trends in resmetirom prescriptions for metabolic dysfunction-associated steatohepatitis in the USA.Clinical and molecular hepatology · 2026Article
- Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors.Nutrients · 2026Review
- Semaglutide for metabolic dysfunction-associated steatohepatitis (MASH): Estimating eligibility from the 2021-2023 National Health and Nutrition Examination Survey (NHANES).Hepatology communications · 2025Article
- Low awareness of MASLD among U.S. adults: Trends from NHANES 2017-2023.Hepatology communications · 2025Article
- Non-invasive tests fail to ensure therapeutic precision for resmetirom in MASLD.Hepatology forum · 2025Article
- Non-invasive tests for resmetirom treatment fail to accurately define the target population: Evidence from a biopsy-proven MASLD cohort.Hepatology forum · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundResmetirom received FDA approval for treating adults with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) and moderate-to-advanced liver fibrosis (stages F2-F3). Here, we sought to estimate the eligible U.S. adult population for resmetirom therapy, with secondary analysis focusing on individuals with type 2 diabetes mellitus (T2DM).
methodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 cycle. Two eligibility scenarios were examined: a liberal scenario requiring ALT >17 U/L for women or >20 U/L for men, controlled attenuation parameter (CAP) >280 dB/m, and liver stiffness measurement (LSM) >8 kPa; and a restrictive scenario requiring ALT >30 U/L for both sexes, CAP >280 dB/m, and LSM >10 kPa. The analysis incorporated sampling weights to generate nationally representative estimates.
resultsThe study cohort included 7244 adults (mean age 49.08 y, 49.9% male) with a mean BMI of 29.61 kg/m², mean CAP 263.35 dB/m, and mean LSM 5.8 kPa. An estimated 8.3 million (95% CI: 6.6-9.9 million) adults met the liberal eligibility criteria, while 2.3 million (95% CI: 1.4-3.2 million) met the restrictive criteria. Patients meeting restrictive criteria were predominantly male (76.2% vs. 59.9%) and younger (mean age 46.7 vs. 48.3 y), with similar BMI (38.6 vs. 38.1 kg/m²). Among adults with T2DM, 3.5 million (95% CI: 2.4-4.5 million; 12.2%) met liberal, whereas 0.85 million (95% CI: 0.5-1.2 million; 3.0%) restrictive criteria.
conclusionsA substantial proportion of U.S. adults meet eligibility criteria for resmetirom treatment, with estimates varying significantly based on the stringency of selection criteria.
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