Evidence map›Paper›PMID 40536473›Full record

ArticleOncoimmunology2025

Cancer cells accelerate exhaustion of persistently activated mouse CD4

Malgorzata Stachowiak, William J Becker, Purevdorj B Olkhanud, Paloma A Moreno, Sergiusz Markowicz, Jay A Berzofsky, Elzbieta Sarnowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. CD4Cancer biology & medicine · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Malgorzata StachowiakDepartment of Experimental Immunotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0002-0151-2417
William J BeckerVaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8807-5522
Purevdorj B OlkhanudVaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3336-376X
Paloma A MorenoVaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sergiusz MarkowiczDepartment of Experimental Immunotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0003-1280-6514
Jay A BerzofskyVaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0342-3194
Elzbieta SarnowskaDepartment of Experimental Immunotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0001-7723-1198

Funding

Antigen-specific T-cell activation, vaccines for CancerZ01SC004020 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI BERZOFSKY, JAY A · 1996 to 2008
$3.8M
Intramural NIH HHS Z01 SC004020
6 · The paper itself

Abstract

Most exhaustion studies have focused on CD8

Indexed as

CD4-Positive T-LymphocytesColorectal NeoplasmsLymphocyte ActivationAnimalsB7-H1 AntigenCell Line, TumorCytokinesHumansInterferon-gammaLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorB7-H1 AntigenCd274 protein, mouseCytokinesInterferon-gammaProgrammed Cell Death 1 ReceptorCD4+ T cell exhaustionmouse colorectal cancer cellsPD-L1 expression

Identifiers

PMID40536473
PMCPMC12184148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.