ArticleJACC. Clinical electrophysiology2025
Age-Specific Mechanisms of Sudden Death Associated With Epilepsy.
Article in JACC. Clinical electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond cardiac risk factors: non-cardiovascular comorbidities in sudden cardiac death prediction.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundEpilepsy is associated with an increased risk of sudden cardiac death (SCD), which can occur at any age. Due to low numbers of SCD events in longitudinal cohort studies of epilepsy, studies of age-specific clinical profiles have not been performed.
objectivesIn this study, the authors investigated the detailed clinical characteristics of SCD associated with epilepsy in the general population, across all ages.
methodsIndividuals with a pre-SCD diagnosis of epilepsy were identified from all out-of-hospital SCD cases prospectively ascertained in Portland, Oregon since 2002 (catchment population ∼1 million) and Ventura County, California since 2015 (catchment population ∼850,000). Lifetime clinical records were evaluated for a detailed assessment of the clinical profile.
resultsFrom a total of 8,287 SCD cases, we identified 356 (4.3%) with a pre-SCD history of epilepsy. The proportion of previously diagnosed epilepsy in overall SCD cases was highest among younger subjects and progressively decreased with age (from 35.3% in 1 to 10 years to 2.5% in >80 years) (P < 0.001). There was a distinct shift in the clinical profile demarcated by the 50 to 60 years decade: Younger subjects had the highest prevalence of drug-resistant epilepsy and prearrest seizures (P < 0.001). Older subjects had a significantly higher prevalence of stroke and mood disorders, and these differences were specific for SCD in epilepsy (P < 0.001).
conclusionsThere were significant clinical profile differences by age among individuals with epilepsy, which were observed to be specific for SCD. Age-specific mechanisms should facilitate the development of targeted prevention strategies for SCD in epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.