Evidence map›Paper›PMID 40536446›Full record

ArticleBiomarkers in medicine2025

The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction.

Zhao Ma, Meichen Sun, Baoen Zhang, Yifei Nie, Chenchen Tu, Xin Zhao, Huihua Li, Dongfeng Zhang, Xiantao Song, Hongjia Zhang

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Zhao MaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Meichen SunDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Baoen ZhangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Yifei NieDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Chenchen TuDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Xin ZhaoDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Huihua LiDepartment of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China.
Dongfeng ZhangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Xiantao SongDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
Hongjia ZhangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe immunoproteasome is linked to endothelial function and may act as a proangiogenic factor. This study explored its predictive value for coronary collateral circulation (CCC) in ST-elevation myocardial infarction (STEMI) patients.

methodsWe enrolled 252 STEMI patients from April 2021 to April 2024. Plasma levels of LMP2, LMP7, and PSMB10 were measured using ELISA. ROC curves assessed predictive ability for good CCC. Univariate and multivariate logistic regression analyses identified predictors, and restricted cubic spline (RCS) analysis evaluated the dose-response relationship. Subgroup analysis was also conducted.

resultsPatients with good CCC had significantly higher plasma levels of immunoproteasome components. Among them, LMP7 showed the best predictive value (AUC = 0.732), with an optimal cut-off of 3.824 ng/mL. Multivariate logistic regression confirmed LMP7 ≥3.824 ng/mL as an independent predictor for good CCC [OR = 7.914 (4.127-15.174)]. RCS analysis showed a J-shaped association: the odds of good CCC increased notably when LMP7 exceeded 3.824 ng/mL. Subgroup analyses supported these findings.

conclusionHigher plasma immunoproteasome levels, especially LMP7 ≥3.824 ng/mL, were independently associated with good CCC in STEMI patients, suggesting its potential role as a biomarker of collateral development.

Indexed as

Collateral CirculationCoronary CirculationCysteine EndopeptidasesProteasome Endopeptidase ComplexST Elevation Myocardial InfarctionAgedBiomarkersFemaleHumansMaleMiddle AgedROC CurveBiomarkersCysteine EndopeptidasesLMP-2 proteinLMP7 proteinProteasome Endopeptidase Complexcoronary collateral circulationImmunoproteasomerestricted cubic splineST-elevation myocardial infarction

Identifiers

PMID40536446
PMCPMC12233720

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