Evidence map›Paper›PMID 40536322›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer.

Deepak S Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel-Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa

Abstract readReviewComparative Study
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deepak S ChauhanDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.ORCID https://orcid.org/0000-0001-8602-6006
Kun ShaoState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116023, China.
Roopa Hebbandi NanjundappaDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Daniel-Jiajun YuFaculty of Pharmacy, Universite de Montreal, Montreal, QC, H3T 1J4, Canada.
Marianne StanfordDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Huile GaoKey Laboratory of Drug-Targeting and Drug Delivery System, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Channakeshava Sokke UmeshappaDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.ORCID https://orcid.org/0000-0002-9867-2141

Funding

Canada Research ChairsCIHRLotte and John Hecht Memorial FoundationThousand Talents Program
6 · The paper itself

Abstract

Photo-responsive/activable nanomedicine-driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti-cancer efficacy. This comprehensive review examines the current advancements in photo-responsive/activable immunomodulator-loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo-responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer.

Indexed as

ImmunotherapyNanomedicineNeoplasmsPhototherapyAnimalsHumansTreatment Outcomeclinical trialsimmunotherapyphotodynamic therapyphotoimmunotherapyphotothermal therapy

Identifiers

PMID40536322
PMCPMC12376634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.