ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Topographical Patterning of Cell-Repellent Interfaces for Immune-Stealth Implantable Electronics via Multiphoton Ablation Lithography.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Topographical Patterning of Cell-Repellent Interfaces for Immune-Stealth Implantable Electronics via Multiphoton Ablation Lithography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Stable and reliable operation of implantable electronics must ensure both high-quality electrical performance and chronic biocompatibility. Here, immune-stealth implantable electronics fabricated by multiphoton ablation lithography are introduced. The cell-repellent interface, consisting of micro-grooves and nano-islands, can be created by laser-assisted topography patterning on a thin film substrate. This patterned surface demonstrates a 20-fold increase in cell-repellent effectiveness against immune cells such as macrophages and fibroblasts due to disturbance of focal adhesion. Furthermore, the cell-repellent interface can also be patterned on the sub-micron electrode layer without compromising its electrical and electrochemical performance. When the electrocardiogram (ECG) sensor applying the cell-repellent interface is implanted into a rat subcutaneous tissue, inflammation and fibrotic reactions are effectively suppressed for 6 weeks. Consequently, stable ECG readings with clear PQRST waveforms are obtained in real-time for 4 weeks, suggesting its potential to enhance chronic biocompatibility of implantable electronics.
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Registered trials
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