ArticleThe British journal of psychiatry : the journal of mental science2025
Reproducible sex differences in personalised functional network topography in youth.
Article in The British journal of psychiatry : the journal of mental science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.bioRxiv : the preprint server for biology · 2026Article
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28 authors.
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Abstract
backgroundA key step toward understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organisation at the critical transition from childhood to adolescence. Prior work suggests that individual differences in the spatial organisation of functional brain networks across the cortex are associated with psychopathology and differ systematically by sex.
aimsWe aimed to evaluate the impact of sex on the spatial organisation of person-specific functional brain networks.
methodWe leveraged person-specific atlases of functional brain networks, defined using non-negative matrix factorisation, in a sample of
resultsSex differences in PFN topography were greatest in association networks including the frontoparietal, ventral attention and default mode networks. Machine learning models trained on participants' PFNs were able to classify participant sex with high accuracy.
conclusionsSex differences in PFN topography are robust, and replicate across large-scale samples of youth. These results suggest a potential contributor to the female-biased risk in depressive and anxiety disorders that emerge at the transition from childhood to adolescence.
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