Evidence map›Paper›PMID 40536191›Full record

ArticleCancer medicine2025

Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer.

Matthew Dietz, Travis J Gates, Rakesh Sikdar, Subbaya Subramanian, Mikael H Elias, Christopher Staley

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew DietzDivision of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Travis J GatesDivision of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Rakesh SikdarBioTechnology Institute, University of Minnesota, St. Paul, Minnesota, USA.ORCID https://orcid.org/0000-0001-9795-8028
Subbaya SubramanianDivision of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Mikael H EliasBioTechnology Institute, University of Minnesota, St. Paul, Minnesota, USA.
Christopher StaleyDivision of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-2309-0083

Funding

Minnesota Colorectal Cancer Research FoundationNorm and Pat Wells Grant
6 · The paper itself

Abstract

backgroundThe gut microbiota is associated with colorectal cancer (CRC) risk and CRC metastatic potential. However, the role of bacteria in CRC progression and metastasis remains unclear.

aimsHere, we hypothesized that microbial communication, mediated through quorum sensing (QS), was a critical component regulating microbial functions related to cancer progression and metastasis. MATERIALS &

methodsTo test this, male and female C57BL/6 mice were injected with organoids modeling aggressive colon cancer (CRC), carrying mutations in Apc, Kras, p53, and Smad4. Two groups of mice were treated with two different quorum quenching (QQ) lactonases (GcL or SsoPox) for 8 weeks (n = 10/group/sex). Fecal samples were collected weekly and characterized by Illumina next-generation sequencing, with tissues collected during necropsy.

resultsMale mice treated with SsoPox had fewer metastases than control mice (χ DISCUSSION: These results suggest that QQ treatment has a sex-based effect on CRC metastatic rate.

conclusionTargeting communication among the gut microbiome may be a promising avenue for the development of CRC therapies that minimally impact microbial community composition and host immune response.

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeQuorum SensingAnimalsDisease Models, AnimalFecesFemaleHumansMaleMiceMice, Inbred C57BLNeoplasm Metastasisautoinducermicrobiomeorganoidquorum quenchingsignaling

Identifiers

PMID40536191
PMCPMC12177794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.