Evidence map›Paper›PMID 40536160›Full record

Observational studyPediatric pulmonology2025

Health-Related Quality of Life After Pediatric Lung Transplantation.

Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf and 1 more

Abstract readObservational Study
In one paragraph

Observational study in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole MartinDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergy and Endocrinology, Comprehensive Centre of Pediatrics, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0009-0008-9867-4447
Edith NachbaurDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergy and Endocrinology, Comprehensive Centre of Pediatrics, Medical University of Vienna, Vienna, Austria.
Zsolt SzépfalusiDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergy and Endocrinology, Comprehensive Centre of Pediatrics, Medical University of Vienna, Vienna, Austria.
Dóra KrikovskyPediatric Center, Semmelweis University, Budapest, Hungary.
Lajos KovácsPediatric Center, Semmelweis University, Budapest, Hungary.
Clemens AignerDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-7787-991X
Konrad HoetzeneckerDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Alberto BenazzoDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Peter JakschDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Alexandra GrafSection for Medical Statistics, Centre for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Saskia GruberDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergy and Endocrinology, Comprehensive Centre of Pediatrics, Medical University of Vienna, Vienna, Austria.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundPediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.

methodsThis observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.

resultsThe study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.

conclusionThis study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.

Indexed as

Lung TransplantationQuality of LifeAdolescentChildChild, PreschoolEmploymentFemaleHumansMaleSurveys and Questionnaireshealth‐related quality of lifepediatric lung transplantationpost‐transplant outcome

Identifiers

PMID40536160
PMCPMC12178106

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.