Trial reportJournal of cosmetic dermatology2025
Benefits of a Multifunctional Sunscreen Formulation Containing Nanoencapsulated Antioxidants in the Skin Protection Against UV Radiation and Blue Light: Clinical and Preclinical Studies.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe development of sunscreens with properties beyond photoprotection involves carefully optimizing the blend of ingredients and employing advanced systems to ensure effective delivery through the skin layers.
aimsThe aim of this study was to evaluate the efficacy of a multifunctional photoprotective formulation containing a blend of nanoencapsulated ingredients-ascorbyl palmitate, caffeine, and resveratrol-and the active ingredients niacinamide, hyaluronic acid, bisabolol, tocopherol, and carnosine in skin protection against UV and blue light radiations, by in vitro, ex vivo, and clinical studies.
methodsA preclinical approach using human explants was performed to evaluate the protective effects of a sunscreen formulation against damage induced by UV and blue light radiation. In addition, a clinical trial was carried out to evaluate skin acceptability, protection from UV-A and UV-B, collagen synthesis by fluorescence spectroscopy, and skin hydration.
resultsThe results of the preclinical study showed that the proposed formulation prevented UV-induced reactive oxygen species (ROS) production and stimulated the levels of epidermal opsin-3 photoreceptors, ensuring melanogenesis control. The clinical study showed that the sunscreen was well-tolerated by both skin and eyes, improved skin conditions by upregulating collagen synthesis, and moisturizing the skin.
conclusionThe combination of the active ingredients in the proposed formulation was safe and effective for skin protection against ultraviolet radiation, besides promoting collagen synthesis and opsin-3 stimulus.
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