Evidence map›Paper›PMID 40536108›Full record

ArticleAutism research : official journal of the International Society for Autism Research2025

Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition.

Chih-Hung Lin, Yong Ren, Kin Wai Tam, Megan Conrow-Graham, Zhen Yan

Abstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Epigenetic treatment of synaptic and behavioral deficits in Dyrk1a-mutant mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chih-Hung LinDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Yong RenDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Kin Wai TamDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Megan Conrow-GrahamDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0002-9996-0786
Zhen YanDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0002-3519-9596

Funding

Synaptic and Genetic Mechanisms of Sex-Specific Effects of StressR01MH126443 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YAN, ZHEN · 2021 to 2025
$2.7M
Epigenetics-Based Autism Treatment with Animal Models and Human Stem CellsR01NS127728 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JIAN FENG, Zhen Yan · 2023 to 2026
$2.5M
NIH HHS MH126443NIH HHS NS127728NIMH NIH HHS R01 MH126443NINDS NIH HHS R01 NS127728
6 · The paper itself

Abstract

ADNP (Activity-dependent neuroprotective protein) is a top-ranking autism risk gene. Here we examined synaptic alterations in heterozygous mice carrying an autism mutation on Adnp C-terminus (Adnp

Indexed as

Autistic DisorderHistone DemethylasesNerve Tissue ProteinsSynapsesSynaptic TransmissionAnimalsDisease Models, AnimalExcitatory Postsynaptic PotentialsFemaleInhibitory Postsynaptic PotentialsMaleMiceMutationPrefrontal CortexPyramidal CellsHistone DemethylasesKDM1a protein, mouseNerve Tissue Proteins

Identifiers

PMID40536108
PMCPMC12257630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.