Evidence map›Paper›PMID 40536098›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Dissection of Neurotropic Theiler's Murine Encephalomyelitis Virus Induced Brain Atrophy in Single MHC Class I Mice of C57BL/6 Background.

Katheryn M Wininger, Katayoun Ayasoufi, Delaney Anani-Wolf, Destin T Hinson, Fang Jin, Michael J Hansen, Aaron J Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katheryn M WiningerNeuroscience Program, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0009-0006-6378-6575
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Delaney Anani-WolfDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Destin T HinsonDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Fang JinDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Michael J HansenDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Aaron J JohnsonNeuroscience Program, Mayo Clinic, Rochester, Minnesota, USA.

Funding

CD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6M
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy - SupplementRF1NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2021 to 2023
$2.0M
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and TauopathyR01NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2024 to 2025
$1.2M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS103212HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS122174NINDS NIH HHS R01 NS103212NINDS NIH HHS R01 NS122174NINDS NIH HHS RF1 NS122174
6 · The paper itself

Abstract

Brain atrophy is a common feature of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and more recently SARS-CoV-2 infection for which the neuroinflammatory mechanism is not fully understood. Nevertheless, neuroinflammation and CD8 T cell accumulation is frequently observed in postmortem brain tissue of patients with neurodegeneration. We therefore developed a murine model of brain atrophy using the Theiler's murine encephalomyelitis virus (TMEV) infection model of multiple sclerosis. We employ single major histocompatibility complex (MHC) class I molecule conditional knockout mice generated by our program to analyze the contribution of immune cell infiltration and onset of atrophy. TMEV infected C57BL/6 mice that singularly express H-2K

Indexed as

BrainCardiovirus InfectionsHistocompatibility Antigens Class IMultiple SclerosisTheilovirusAnimalsAtrophyCD8-Positive T-LymphocytesDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutHistocompatibility Antigens Class Ibrain atrophyCD8 T cellMHC class I moleculemouse modelmultiple sclerosisneurodegenerationneuroinflammationneurotropic virus

Identifiers

PMID40536098
PMCPMC12857587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.