Evidence map›Paper›PMID 40535972›Full record

ArticleFrontiers in neuroscience2025

Mechanistic insights into cadmium-related premature aging in

Maria Dolores De Donno, Ester Mercuri, Barbara Balena, Francesco Zangaro, Maria Pia Bozzetti, Valeria Specchia

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Dolores De DonnoDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
Ester MercuriDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
Barbara BalenaDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
Francesco ZangaroDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
Maria Pia BozzettiDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
Valeria SpecchiaDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intricate and multifaceted relationship between environmental pollutants, particularly heavy metals such as cadmium, and human health has been extensively documented, with a significant focus on their neurotoxic effects. Notably, the connection between cadmium exposure and Alzheimer's disease is becoming increasingly evident, prompting a deeper investigation into the underlying mechanisms at play. Despite the growing body of evidence linking cadmium to neurodegeneration and although harmful molecular activities of cadmium in cells have been demonstrated, the precise molecular mechanism induced by this toxic metal within neuronal cells remains largely enigmatic. This study aims to shed light on these mechanistic processes by utilizing

Indexed as

agingcadmiumcognitive impairmentsDrosophila melanogasterLLPSneurodegeneration

Identifiers

PMID40535972
PMCPMC12174419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.