ArticleFrontiers in neuroscience2025
Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The symptoms of bipolar disorder (BD) may be characterized as disruptions in energy metabolism, and neural energy availability may serve as a mechanistic marker of BD. Lactate, the end product of glycolysis, is a poorly understood neural energy source that may contribute to the neural dysfunction underlying BD. Methods: We aimed to assess precuneus lactate availability during an emotion processing task and during rest in a sample of participants with well-characterized, pediatric-onset BD ( Results: In this small sample, we observed that the difference in precuneus lactate availability between the emotion processing task and rest (e.g., lactate flux) was greater in participants with BD [mean = 0.014 (0.041)] than in healthy controls (HCs) [mean = -0.033 (0.028), Discussion: These results suggest, for the first time, using ultra-high-field strength MRSI with a high signal-to-noise ratio, that lactate flux is dysfunctional in well-characterized BD. Our findings highlight the importance of lactate as a mechanistic marker of BD, which may be used to develop novel treatment options.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.