Evidence map›Paper›PMID 40535782›Full record

ArticleBiochemistry and biophysics reports2025

Blood perfusion through ventricular assist devices induces erythrocytes to interact with leukocytes.

Kylie M Foster, Ahmed M El Banayosy, Zheila Azartash-Namin, Phillip Coghill, James W Long, Edgar O'Rear, Hendra Setiadi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kylie M FosterSchool of Sustainable Chemical, Biological and Materials Engineering, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, 100 East Boyd, Sarkeys Energy Center, Norman, OK 73019, USA.
Ahmed M El BanayosyINTEGRIS Advanced Cardiopulmonary Care, INTEGRIS Baptist Medical Center, 3400 NW Expressway, Ste 200, Oklahoma City, OK 73112, USA.
Zheila Azartash-NaminVADovations Inc., 1333 Cornell Pkwy, Oklahoma City, OK 73108, USA.
Phillip CoghillVADovations Inc., 1333 Cornell Pkwy, Oklahoma City, OK 73108, USA.
James W LongINTEGRIS Advanced Cardiopulmonary Care, INTEGRIS Baptist Medical Center, 3400 NW Expressway, Ste 200, Oklahoma City, OK 73112, USA.
Edgar O'RearSchool of Sustainable Chemical, Biological and Materials Engineering, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, 100 East Boyd, Sarkeys Energy Center, Norman, OK 73019, USA.
Hendra SetiadiINTEGRIS Advanced Cardiopulmonary Care, INTEGRIS Baptist Medical Center, 3400 NW Expressway, Ste 200, Oklahoma City, OK 73112, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantations of Ventricular Assist Devices (VADs) have significantly improved quality of life and life expectancy of end-stage heart failure patients. However, despite the advancements in the VAD designs and patient management protocols, the VAD recipients remain at risk of attaining bleeding, infection, pump thrombosis, and stroke. Although blood trauma has been suggested as a critical factor in development of these adverse events, its consequences in inducing interactions between different types of blood cells are largely unknown. Following our recent findings on erythrocyte and leukocyte trauma in VAD recipients, we decided to explore interactions between erythrocytes and leukocytes by perfusing human whole blood through two different types of VADs, HeartMate II (HMII) and HeartMate 3 (HM3), concurrently in their respective Blood Circulatory Loop (BCL). By using a flow cytometry assay, we found increasing association between erythrocytes and leukocytes as VADs propelled blood through their BCLs. This time-dependent intercellular association was shown by increasing concomitant events of stained CD235a (specifically expressed on erythrocytes) and stained CD45 (specifically expressed on leukocytes) in the CD235a

Identifiers

PMID40535782
PMCPMC12173732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.