ArticleJournal of central nervous system disease2025
Correlation of Cognition With Disability and Physical Performance in Patients With Relapsing-Remitting MS.
Article in Journal of central nervous system disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04115930 (Correlation Between Daily Physical Activity and Disability, Fatigue, Cognition and Quality of Life in MS Patients), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Daily Physical Activity and Disability, Fatigue, Cognition and Quality of Life in MS Patients
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cognitive impairment is common in patients with multiple sclerosis (MS). Physical activity is clearly linked to cognitive performance, and several studies have shown the importance of regular cognition testing, but such testing is still not routinely performed in clinical practice. Objective: This study aimed to investigate the association between cognition, disability, and physical performance in relapsing-remitting MS (RRMS) patients. Methods: A total of 41 patients with RRMS with an Expanded Disability Status Scale (EDSS) level of 0-5.5 and 20 healthy controls completed the MS Functional Composite (MSFC) test and the Symbol Digit Modality Test (SDMT). Six-Minute Walk (6MW) was evaluated for all participants, and they used an accelerometer for seven days. Results: A significant correlation was found between cognition and disability level measured by the MSFC (MSFC/SDMT, r = 0.668, Conclusion: There was a clear association between disability, 6MW and cognition. Better results on the 6MW predicted better cognition and disability.Clinical trial registration number: NCT04115930.
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