ReviewFrontiers in pharmacology2025
Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles.Cancer biology & therapy · 2026Review
- Article
- Identification of a Novel De Novo Heterozygous SEC61A1 Variant in a Patient With Severe Congenital Neutropenia.Molecular genetics & genomic medicine · 2026Article
- SEC61: a potential therapeutic target in transplantation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Sec61 complex, which is located on the membrane of the mammalian endoplasmic reticulum (ER), serves as a pivotal component of protein transport channels. It plays a central role in the transport of nascent peptides and precursor peptides to the ER. This process includes the directed movement of precursor peptides to the ER membrane and the opening of the Sec61 transduction channel for translocation. The Sec61 channel not only plays a key role in transporting peptides into cells but also acts as a passive ER Ca
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Registered trials
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