ArticleWorld journal of otorhinolaryngology - head and neck surgery2025
Noise and the risk of tinnitus: A two-sample Mendelian randomized study.
Article in World journal of otorhinolaryngology - head and neck surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex.Cellular and molecular neurobiology · 2025Article
- Noise and the risk of tinnitus: A two-sample Mendelian randomized study.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Observational studies imply that noise may increase the likelihood of developing tinnitus. However, no causal relationship has been established between the two using Mendelian randomization (MR) analysis, we aimed to determine the potential causal relationship between noise and various categories of tinnitus. Methods: We extracted single nucleotide polymorphisms (SNPs) associated with noise and tinnitus from a large genome-wide association study (GWAS) of European individuals. UK Biobank (UKB) provided summary data for both entities. Inverse variance weighting (IVW) was implemented as the primary method for evaluating effect estimates. Using Weighted median and MR-Egger regression, heterogeneity and pleiotropy were evaluated using sensitivity analyses. Results: The random-effects IVW approach revealed a causal relationship between noise and the three onset tinnitus (odds ratio [OR] = 1.052, 95% confidence interval [CI] = 1.013-1.092, Conclusion: This Mendelian Randomization study provides causal evidence that noise is a risk factor for the onset of tinnitus but is not a risk factor for developing tinnitus in the past.
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Registered trials
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