ArticleWorld journal of otorhinolaryngology - head and neck surgery2025
Diagnostic value of fasting hypopharyngeal salivary pepsin concentration test for laryngopharyngeal reflux disease.
Article in World journal of otorhinolaryngology - head and neck surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Salivary Pepsin Test in the Diagnosis of Laryngopharyngeal Reflux Disease: Reality or Fallacy?World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Diagnostic value of fasting hypopharyngeal salivary pepsin concentration test for laryngopharyngeal reflux disease.World journal of otorhinolaryngology - head and neck surgery · 2025Article
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Authors and funding
7 authors.
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Abstract
Objective: To investigate the diagnostic value of the fasting hypopharyngeal salivary pepsin concentration test for laryngopharyngeal reflux disease (LPRD). Methods: Volunteers were grouped by reflux symptom index scale, reflux finding score scale, and 24-h hypopharyngeal-esophageal multichannel intraluminal impedance with pH monitoring results. The study comprised 56, 27, and 20 individuals in the LPRD, asymptomatic laryngopharyngeal reflux (LPR), and asymptomatic non-LPR groups, respectively. All underwent a fasting hypopharyngeal saliva pepsin testing via enzyme-linked immunosorbent assay. Statistical analysis determined the optimal diagnostic cutoff value, sensitivity, and specificity of hypopharyngeal salivary pepsin for LPRD. Correlation analysis was performed with reflux scale scores and LPR parameters. Results: Fasting hypopharyngeal salivary pepsin concentration in the LPRD group was significantly higher than in the asymptomatic control group ( Conclusions: The fasting hypopharyngeal salivary pepsin concentration test is a highly specific, simple, and noninvasive method with significant clinical diagnostic value for LPRD.
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