ArticleAmerican journal of translational research2025
Elevated KLF2 and YKL-40 with reduced vitamin A as predictive biomarkers for severity and prognosis in neonatal respiratory distress syndrome.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Retrospective cohort study on the correlation between serum 25(OH)D, vitamin A and neonatal respiratory distress syndrome (NRDS) in premature infants.Translational pediatrics · 2025Article
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2 authors.
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Abstract
objectiveThis study aimed to investigate the relationships between Krüppel-like factor 2 (KLF2), YKL-40, and vitamin A levels, as well as their association with the severity and prognosis of Neonatal Respiratory Distress Syndrome (NRDS), with the goal of improving predictive accuracy and clinical management.
methodsA retrospective cohort study was conducted at Bozhou Municipal People's Hospital between January 2019 and January 2022. A total of 128 neonates diagnosed with NRDS were included, along with 128 healthy neonates as controls. Blood samples were collected within one hour of admission. Levels of KLF2, YKL-40, and vitamin A were measured using enzyme-linked immunosorbent assay (ELISA) and high-performance liquid chromatography (HPLC). Neonates were grouped based on NRDS severity, and the relationships between biomarker levels and clinical outcomes were analyzed.
resultsSignificant differences in KLF2, YKL-40, and vitamin A levels were observed between the NRDS group and control group (
conclusionKLF2, YKL-40, and vitamin A are significant biomarkers for predicting the severity and prognosis of NRDS. Combining these biomarkers enhances predictive accuracy, aiding in the early identification and personalized management of neonates with NRDS.
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