ReviewAmerican journal of translational research2025
Progress in macrophage immune regulation of atherosclerosis.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mitochondrial Dysfunction: From Molecular Mechanisms to Modern Approaches for Basic and Clinical Research.Biomedicines · 2026Review
- Macrophage microRNAs integrating lipid metabolism and inflammation: Implications for atherosclerosis.Metabolism open · 2026Review
- Novel insights of ferroptosis in atherosclerosis progression.Frontiers in cell and developmental biology · 2026Review
- Vulnerable plaques in atherosclerosis: focus on angiogenesis-associated phenotypic crosstalk.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a chronic inflammatory disease that contributes to cardiovascular conditions, including coronary artery disease and stroke. Macrophages are central to its pathogenesis, accumulating in arterial walls, engulfing oxidized low-density lipoprotein (oxLDL), and forming foam cells that exacerbate inflammation. These macrophages can polarize into two main subsets: M1 macrophages, which promote inflammation, and M2 macrophages, which resolve inflammation and support tissue repair. The balance between these subsets is crucial for plaque progression and stability. Recent studies have elucidated the immune regulatory functions of macrophages in modulating atherosclerotic plaque formation and vulnerability. Understanding the mechanisms governing macrophage activation, polarization, and immune interactions presents promising therapeutic targets aimed at stabilizing plaques and preventing cardiovascular events. This review summarizes current research on the role of macrophages in atherosclerosis and discusses potential therapies targeting macrophage immune regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.