ArticleAmerican journal of translational research2025
Prospective study of continuous low-dose norepinephrine infusion during induction of anesthesia: effects on the stability of blood pressure and recovery quality in elderly patients undergoing robotic radical prostatectomy.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
objectiveTo assess the effect of low-dose norepinephrine infusion on hemodynamic changes during anesthesia induction and its correlation with postoperative recovery in elderly patients undergoing robot-assisted radical prostatectomy.
methodsA prospective observational study was conducted on 63 elderly patients divided into two groups: the norepinephrine group (NE group) receiving 2-5 μg/kg·h norepinephrine by injection pump during anesthesia induction, and the control group (C group) with regular anesthesia. Heart rate (HR) and invasive blood pressure (BP) were recorded at four time points: before induction, pre-intubation lowest value (T1), post-intubation (T2), and lowest BP between intubation and skin incision (T3). Postoperative recovery (QoR-15) was evaluated on Days 1 and 3.
resultsStatistically significant differences in systolic (SBP) and diastolic blood pressure (DBP) were observed between groups at T1 and T3 (P<0.05), but no significant differences in HR were found at any time point (P>0.05). The NE group had significantly higher SBP, DBP, and HR at T1 and T3 compared to the C group (P<0.05). Hemodynamic stability was significantly better in the NE group (P<0.05). No significant differences were seen in QoR-15 scores or postoperative hospital stay between groups (P>0.05), but the Barthel Index increased significantly in the NE group (P<0.05).
conclusionsContinuous low-dose norepinephrine infusion effectively reduced blood pressure and heart rate fluctuations during anesthesia induction. However, the study showed only a weak correlation between intraoperative hemodynamic changes and postoperative recovery.
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