ArticleFrontiers in cellular and infection microbiology2025
Comparison of bronchoalveolar lavage fluid mNGS and sputum culture in the clinical application of severe pneumonia.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mapping the Evolution of Diagnostic Research onPathogens (Basel, Switzerland) · 2026Review
- Article
- Metagenomic next-generation sequencing for the diagnosis and evaluation of pediatric pleural effusion: a case series.BMC pulmonary medicine · 2026Article
- Article
- Case Report: Isolated diffuse alveolar hemorrhage as the sole severe manifestation of atypical leptospirosis without jaundice or acute kidney injury and the diagnostic value of BALF metagenomic next-generation sequencing.Frontiers in medicine · 2026Article
- Application of metagenomic next-generation sequencing technology in hematologic malignancy patients with sepsis following antibiotic use.BMC infectious diseases · 2025Article
- Clinical characteristics ofFrontiers in cellular and infection microbiology · 2025Article
- Structural and Functional Alterations of Microbiome in Upper and Lower Respiratory Tract in Patients With NSCLC.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
6 authors.
Funding
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Abstract
Objective: The purpose of this study is to compare the clinical application value of bronchoalveolar lavage fluid (BALF) mNGS and sputum culture in severe pulmonary infections, and to provide guidance for clinicians in selecting the appropriate testing method. Methods: This study collected 105 patients diagnosed with severe pneumonia, of which 55 patients who underwent BALF mNGS. We compared the pathogen detection rates, length of stay and mortality rate, treatment, and pathogen species between BALF mNGS group and sputum culture group. Results: The pathogen detection rate in BALF mNGS group was significantly higher than that in sputum culture group ( Conclusion: BALF mNGS effectively and rapidly identifies pathogens, helping doctors quickly diagnose severe pneumonia pathogens. Combined with the patient's medical history, laboratory results and imaging, clinical doctors can adjust the patient's treatment plan in time. This has potential advantages in improving the cure rate of severe pneumonia patients, reducing the length of hospital stay, and improving the prognosis.
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