Evidence map›Paper›PMID 40535481›Full record

ArticleWorld journal of transplantation2025

Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined.

William H Archie, Maria Baimas-George, Nathanael Haynes, Souma Kundu, Katheryn Peterson, Chase J Wehrle, Damien Huckleberry, Lon Eskind, David Levi, Jose R Soto and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

William H ArchieDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States. william.archie@atriumhealth.org.
Maria Baimas-GeorgeDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Nathanael HaynesDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Souma KunduDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Katheryn PetersonDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Chase J WehrleDepartment of Hepato-Pancreato-Biliary/Liver Transplant Surgery, Cleveland Clinic Transplant Research Center, Cleveland, OH 44195, United States.
Damien HuckleberryDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Lon EskindDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
David LeviDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Jose R SotoDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Roger DennyDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Vincent CasingalDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Allyson CochranDepartment of Surgery, Carolinas Center for Surgical Outcomes Science, Carolinas Medical Center, Charlotte, NC 28203, United States.
Erin H ReinDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.
Dionisios VrochidesDivision of Adominal Transplant, Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe normothermic machine perfusion pump (NMPP) could shape the future of transplantation. Providing

aimTo investigate the relationship between MPT and post-transplant graft function.

methodsRetrospective review of the first 50 donation after circulatory death (DCD) grafts preserved using NMPP in a tertiary institution was performed. Essential preservation time points, graft parameters, recipient information, and postoperative outcomes were prospectively recorded. Early allograft dysfunction (EAD), L-Graft

resultsNMPP operational parameters were not predictive of EAD, L-GrAFT

conclusionIncreased MPT of DCD liver grafts had no adverse recipient results for the times utilized in this population, indicating its upper limits, likely beyond 24 hours, are not demonstrated within this study. Future studies are necessary to determine whether longer MPT is beneficial or detrimental to graft function and, if the latter, what is the maximum safe duration. Further studies of the effect of normothermic machine perfusion pump duration on long-term outcomes are also needed.

Indexed as

Donation after circulatory deathEx-vivo perfusionIschemic cholangiopathyLiver transplantNormothermic machine pump perfusion

Identifiers

PMID40535481
PMCPMC11886305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.