ArticleActa histochemica et cytochemica2025
Horizontal Imaging of Skin Tumors Using Advanced Fluorescence Techniques for Detecting Individual Malignant Cells.
Article in Acta histochemica et cytochemica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Photodynamic technology for delineating surgical margins in recurrent extramammary Paget's disease: a case report.Frontiers in medicine · 2026Article
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11 authors.
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Abstract
Conventional histopathological techniques, such as hematoxylin and eosin staining, are limited to 4-5 μm-thick tissue sections, restricting visualization to two-dimensional planes. Moreover, acquisition of three-dimensional horizontal images from the skin surface remains challenging, hindering precise assessment of tumor margins in skin lesions. This challenge is particularly pronounced in extramammary Paget's disease (EMPD), in which diffuse epidermal tumor cell spread complicates accurate evaluation of lesion extent. We hypothesized that combining horizontal sectioning with identification of individual tumor cells would enhance the determination of surgical margins. In this study, we developed a deep-imaging technique utilizing fluorescent solvatochromic dyes (LipiORDER
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