Evidence map›Paper›PMID 40535465›Full record

ReviewThe World Allergy Organization journal2025

The effects of prenatal vitamin D supplementation on respiratory and allergy-related outcomes in children: A systematic review and meta-analysis of randomized controlled trials.

Qin Li, Xiaoshuang Xu, Ying Liu, Shao Yin, Qian Hu, Qiang Ji, Yue Zhong, Fengya Zhu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The World Allergy Organization journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qin LiPediatric Immunology and Rheumatology Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaoshuang XuDepartment of Pediatric Urology Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Ying LiuChengdu University of Traditional Chinese Medicine, Chengdu, China.
Shao YinChengdu University of Traditional Chinese Medicine, Chengdu, China.
Qian HuMeishan City People's Hospital, Meishan, China.
Qiang JiZigong First People's Hospital, Zigong, China.
Yue ZhongZigong First People's Hospital, Zigong, China.
Fengya ZhuZigong First People's Hospital, Zigong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin D is critical for immune regulation and respiratory health, yet its supplementation during pregnancy shows inconsistent results in preventing respiratory and allergy-related outcomes in children. This systematic review and meta-analysis aim to evaluate the impact of maternal vitamin D supplementation on respiratory tract infections (RTI), asthma, wheezing, eczema, and allergy in offspring. Methods: A comprehensive search was performed in PubMed, Embase, Web of Science, Cochrane Library up to December 2024. We included randomized controlled trials (RCTs) examining the effects of prenatal vitamin D supplementation on respiratory and allergy-related outcomes in children. The GRADE approach was applied to assess the quality of evidence, and the Cochrane risk-of-bias tool was used to evaluate study quality. Results: Seven RCTs were included (3958 mother-infant pairs). Prenatal vitamin D supplementation did not significantly reduce RTI in children compared to controls (RR = 1.018, 95% CI: 0.965 to 1.074, p = 0.514). Similarly, no significant effects were observed for asthma (RR = 0.395, 95% CI: 0.670 to 1.308, p = 0.699), wheezing (RR = 0.824, 95% CI: 0.826 to 1.089, p = 0.174), eczema (RR = 0.954, 95% CI: 0.826 to 1.102, p = 0.522), allergic conditions (RR = 0.938, 95% CI: 0.841 to 1.047, p = 0.255), or IgE positivity (RR = 0.942, 95% CI: 0.736 to 1.207, p = 0.639). Subgroup analyses showed no significant effect modification based on control group supplementation or follow-up duration. Conclusion: There is moderate-quality evidence suggesting that prenatal vitamin D supplementation has minimal or no significant effect on reducing respiratory tract infections and allergy-related outcomes in children.

Indexed as

Allergic conditionsPregnancy outcomesRespiratory tract infectionsSystematic reviewVitamin D

Identifiers

PMID40535465
PMCPMC12174595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.