Evidence map›Paper›PMID 40535396›Full record

ArticleCureus2025

A Diagnostically Challenging Case of Typical Hemolytic Uremic Syndrome Successfully Treated With Eculizumab Therapy.

Adarsh Jha, Georgette Nader, Sumugdha Rayamajhi, Muhammad Hamdan

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adarsh JhaInternal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Georgette NaderInternal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Sumugdha RayamajhiInternal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Muhammad HamdanHematology and Oncology, Sparrow Hospital, Lansing , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that induces microvesicular injury and occlusion and often results in acute renal failure. Atypical HUS is life-threatening and often progresses to end-stage renal disease (ESRD). However, distinguishing between typical and atypical HUS can be challenging due to comorbid conditions and/or laboratory delays. We present a severe case of typical HUS involving a series of complications requiring multidisciplinary care, successfully treated with eculizumab therapy.

Indexed as

bleeding per rectumhemolysishemolytic uremic syndromemicroangiopathyschistocytes

Identifiers

PMID40535396
PMCPMC12174476

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.