ArticleCureus2025
Solitary Langerhans Cell Histiocytosis of the Femur in a Nine-Month-Old Girl.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder of myeloid dendritic cells that can mimic infection or malignancy in paediatric bone lesions. A 9-month-old girl presented with a refusal to weight bear for two days. She was afebrile with mildly elevated inflammatory markers, including C-reactive protein (CRP) of 2 mg/L and white cell count (WCC) of 12×10⁹/L. Radiographs revealed an aggressive lytic lesion in the proximal femur with periosteal reaction. MRI showed a subperiosteal fluid collection suggestive of abscess, bone marrow edema, and adjacent muscle inflammation. The patient underwent curettage of the lesion. Histopathology confirmed LCH, with immunohistochemistry positive for cluster of differentiation (CD)1a, S100, CD68, and Langerin. Molecular analysis detected a
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