Evidence map›Paper›PMID 40535354›Full record

ArticleJournal of inflammation research2025

Feedback Regulation of sPLA2-COX/5-LOX-Ca2+ in Seminal Plasma and Its Impact on Sperm Quality Parameters.

Yongjie Liu, Liang Dai, Fan Zhang, Yang Liu, Xu Li, Wenzhi Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yongjie LiuReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.
Liang DaiReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.
Fan ZhangReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.
Yang LiuReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.
Xu LiReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.
Wenzhi MaReproductive Medical Center, Yinchuan Maternity and Child Health Care Hospital, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Male reproductive health is of growing concern. Sperm quality declines due to multiple factors. The role of AA metabolic network in sperm quality is unclear, and AA/COX's protection under heat stress needs study. Aim: This study aimed to investigate the relationship between seminal plasma arachidonic acid (AA) metabolic network markers and sperm quality, as well as explore the protective effects of AA and cyclooxygenase (COX) on sperm under heat stress. Methods: We analyzed 164 seminal plasma samples from 164 male infertility patients, categorized by sperm concentration and motility (PR < 32% vs PR ≥ 32%). A heat-stressed weak spermatogenesis model (37-42°C) was established, and AA/COX were added in vitro to assess their impact on sperm quality. Results: Significant correlations were found between AA pathway markers (PL, sPLA2, AA, COX1/2, PGE1, PGF2α, 5-LOX, LTB4) and sperm parameters (motility, acrosome reaction, mitochondrial function, DNA fragmentation). A predictive model combining PL, AA, and COX1 effectively assessed sperm quality. In vitro, 100 pg AA ± 300 pg COX1 protected sperm at 42°C by upregulating COX2, PGE1, and PGF2α while reducing LOX/LTB4 and modulating Ca² Conclusion: Seminal plasma AA metabolism strongly influences sperm quality, likely via sPLA2-COX/5-LOX-Ca²

Indexed as

positive and negative feedbackqualityseminal plasmaspermatozoasPLA2-COX/5-LOX-Ca2+

Identifiers

PMID40535354
PMCPMC12174913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.