ArticleJournal of biotechnology and biomedicine2025
Differential Gene Expression in Rheumatoid Arthritis: Implication in the Diagnosis and Individualized Treatment Plan.
Article in Journal of biotechnology and biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Global temporal trends and projections of rheumatoid arthritis incidence among women of childbearing age: age-period-cohort analysis 2021.Clinical rheumatology · 2026Article
- Immunological heterogeneity in rheumatoid arthritis: challenges in early-stage stratification, non-response to targeted therapy, and the restoration of immune tolerance.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of the joints due to the involvement of biologic, environmental, and genetic factors. Due to its pathogenesis being multifactorial in origin, the underlying molecular mechanisms contributing to the development of RA remain unclear. Therefore, understanding the factors driving RA is crucial for developing targeted therapies and improving patient outcomes. With various genetic variants contributing to RA, this article explores the role of differential gene expression in patients with RA and in different ethnic populations and how the genes contribute to RA susceptibility. Key takeaways from this review demonstrate how HLA shared epitope alleles and non-HLA genes have a strong association with RA and play an important role in immune regulation, autoantibody production, cytokine production, and development of extra-articular manifestations observed in RA. Additionally, gene expression in RA can vary across different sexes and ethnic populations, emphasizing the importance of developing personalized therapeutic interventions. These findings provide insight into the role of differential gene expression in improving diagnostic and therapeutic strategies and highlights potential therapeutic targets for RA management. Future research is needed to determine the clinical relevance of differential gene expression in developing interventions for RA treatment.
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Registered trials
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