Short-term outcomes of off-pump vs. on-pump coronary artery bypass grafting in left main coronary artery disease: a systematic review and meta-analysis.

Lucas Nogueira Pansani, Pedro Emanuel de Paula Carvalho, Douglas Gewehr, Maurizio Taramasso, Giullia Burkhardt, Lara Almeidinha, Rafael Ayala, Martin Tobias Robert Grapow

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In one paragraph

Article in Indian journal of thoracic and cardiovascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lucas Nogueira PansaniDepartment of Cardiovascular Surgery of Funfarme/Famerp, Avenue Brigadeiro Faria Lima, São José do Rio Preto, SP Postal Code 15090-000 Brazil.ORCID 0009-0001-4499-3441

Pedro Emanuel de Paula CarvalhoDepartment of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Douglas GewehrCuritiba Heart Institute, Curitiba, Brazil.

Maurizio TaramassoHeart Center Hirslanden Hirslanden, Zurich, Switzerland.

Giullia BurkhardtDepartment of Medicine, Petropólis Medical School, Petrópolis, Brazil.

Lara AlmeidinhaDepartment of Internal Medicine, General Hospital Rochester, Rochester, USA.

Rafael AyalaDepartment of Cardiovascular Surgery, Robert Bosch Hospital, Stuttgart, Germany.

Martin Tobias Robert GrapowHeart Center Hirslanden Hirslanden, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The efficacy and safety of off-pump relative to on-pump coronary artery bypass grafting (CABG) in patients with left main coronary artery disease (LMCAD) remain unclear. Objectives: Conduct a meta-analysis assessing the outcomes following CABG comparing off-pump CABG vs. on-pump CABG. Methods: MEDLINE, Cochrane, and Embase were examined for randomized controlled trials (RCTs) and observational studies that communicated outcomes after off-pump vs. on-pump CABG in patients with LMCAD. Odds ratios (OR) with 95% confidence intervals (CI) were pooled with a random-effects model. Cochrane recommendations for quality assessment and risk of bias were performed. This study was registered in the PROSPERO platform, ID: CRD42023451467. Results: One RCT and 17 observational studies with 16,848 patients were included, 6735 (40.0%) of whom underwent off-pump CABG. In patients with LMCAD undergoing CABG, off-pump CABG was associated with a lower incidence of all-cause mortality (OR 0.52, 95% CI 0.38-0.71; Conclusion: In this meta-analysis with 16,848 patients with LMCAD undergoing CABG, off-pump CABG was associated with lower rates of all-cause mortality, acute renal dysfunction, IABP use, and wound infection compared with on-pump CABG. Graphical Abstract: On-pump versus off-pump CABG in patients with LMCAD. Supplementary Information: The online version contains supplementary material available at 10.1007/s12055-025-01907-w.

Indexed as

Cardiopulmonary bypass surgeryLeft main coronary artery diseaseOff-pump coronary artery bypass graft surgeryOn-pump coronary artery bypass graft surgery

Identifiers

PMID40535226

DOI10.1007/s12055-025-01907-w

PMCPMC12170468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.