Evidence map›Paper›PMID 40535149›Full record

SynthesisFrontiers in cardiovascular medicine2025

Transcatheter aortic valve replacement in quadricuspid aortic valve: a systematic review and meta-analysis.

Mostafa A Khalifa, Hashim Talib Hashim, Aya Ahmed Shimal, Fathima Raahima Riyas Mohamed, Srinithi Ragunathan, Ahmed Sermed Al Sakini, Mohamed H Elbadawi, Mohammed Rushdhi Irfan, Ibrahim Moqbel, Marwah Mohammed Almualed and 2 more

Erratum issuedAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mostafa A KhalifaFaculty of Medicine, Cairo University, Cairo, Egypt.
Hashim Talib HashimCollege of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq.
Aya Ahmed ShimalCollege of Medicine, University of Baghdad, Baghdad, Iraq.
Fathima Raahima Riyas MohamedCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Srinithi RagunathanPanimalar Medical College and Research Institute, Chennai, India.
Ahmed Sermed Al SakiniCollege of Medicine, University of Baghdad, Baghdad, Iraq.
Mohamed H ElbadawiFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Mohammed Rushdhi IrfanCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Ibrahim MoqbelFaculty of Medicine, Cairo University, Cairo, Egypt.
Marwah Mohammed AlmualedCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohammedbaqer Al-GhuraibawiCollege of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq.
Batool S Al-AboudiFaculty of Medicine, University of Kufa, Najaf, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While Transcatheter Aortic Valve Replacement (TAVR) is now a standard treatment for severe aortic stenosis, its use in patients with quadricuspid aortic valves (QAV) presents unique challenges. This review analyzes current evidence to guide clinicians in managing aortic stenosis in this complex valve morphology. Method: Following PRISMA guidelines, a comprehensive literature search was conducted across multiple databases up to August 15, 2024. A random-effects model was used for meta-analysis, focusing on 30-day mortality and procedural success, with secondary outcomes including paravalvular leak incidence, pacemaker insertion, hemodynamic changes, and NYHA functional class improvement. Results: A total of 11 case reports/series were analyzed, involving 17 adult patients with QAV. Participants had a mean age of 73.80 ± 5.07 years. The mean left ventricular ejection fraction was 41.6%, and the mean annulus area was 595.5 mm Conclusion: TAVR is an effective and growing treatment for high-risk patients with aortic valve disease, including those with QAV. While it has high success rates and challenges (i.e., post-operatively). Future studies should focus on long-term valve durability.

Indexed as

aortic stenosisprocedural successquadricuspid aortic valvesQVAtranscatheter aortic valve replacement

Identifiers

PMID40535149
PMCPMC12175154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.