ArticleOncology letters2025
High-grade corded and hyalinized endometrioid carcinoma with high microsatellite instability and STK11 mutation: A case report and literature review.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Corded and hyalinized endometrioid carcinoma (CHEC) is a rare morphological variant of EC, characterized by biphasic histological characteristics. CHEC are predominantly low-grade, while high-grade CHEC is exceedingly rare in clinical practice. The present study reports a case of CHEC with a high-grade component in a 38-year-old female patient. Morphologically, well-differentiated EC was observed alongside corded components in the hyalinized degenerated mesenchymal tissue in the low-grade region. In the high-grade region, poorly differentiated epithelial cells, faintly visible hyalinized stroma and high nuclear grade spindle-shaped cells were observed. Immunohistochemistry demonstrated the diffuse nuclear expression of β-catenin in tumor cells. Next-generation sequencing revealed β-catenin and PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) gene mutations in both the low- and high-grade regions. Notably, the high-frequency type of microsatellite instability and mutations in serine/threonine kinase 11 were detected exclusively in the high-grade CHEC. The present study reports a case of high-grade CHEC, and simultaneously performed a review of the literature, identifying seven similar cases. Due to the rarity of such cases and the limited knowledge regarding their pathological features, there is a high risk of misdiagnosis. Further accumulation of cases is necessary to characterize CHEC.
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