ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2025
Implementation of Methicillin-Resistant
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveRecent literature supports the use of methicillin-resistant
methodsThis single center, pre- and post-interventional, retrospective cohort study compared antibiotic regimens in pediatric patients treated empirically with anti-MRSA antibiotics, with and without MRSA nasal PCRs. Use of MRSA nasal PCRs in the pediatric hospital was encouraged following an antimicrobial stewardship provider-led continuing education presentation. The primary outcome was duration of therapy of anti-MRSA antibiotics in days. Secondary outcomes included positive predictive values (PPVs) and negative predictive values (NPVs) for all infections, pneumonia, and skin and soft tissue infections.
resultsA total of 319 patients were included in the study, 252 in the pre-intervention group and 67 in the post-intervention group. The duration of anti-MRSA antibiotic therapy in the pre-intervention group was 6.6 days compared with the post-intervention group at 2.0 days (p value = 0.027). Using data from 38 patients with concordant culture results for the infectious diagnosis, overall NPV was calculated as 92.1%. Skin and soft tissue infections and pneumonia were found to have NPVs of 90.1% (22 patients) and 100% (5 patients), respectively.
conclusionImplementation of MRSA nasal PCRs in pediatric patients significantly reduced the duration of anti-MRSA antibiotic therapy, promoting their utility for antimicrobial stewardship.
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