Evidence map›Paper›PMID 40534906›Full record

ArticleSurgery in practice and science2025

Effects of verapamil on intestinal injury in a rat model of acute mesenteric ischemia.

Silvana N Wilken, Diego V Santos Rodrigues, Colin Price, Julia Jacobs, Jack Nelson, Patrick F Walker, Jonathan J Morrison

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery in practice and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Silvana N WilkenDepartment of Surgery, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.
Diego V Santos RodriguesDivision of Vascular and Endovascular Surgery, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.
Colin PriceDivision of Vascular and Endovascular Surgery, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.
Julia JacobsDepartment of Comparative Medicine, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.
Jack NelsonDivision of Vascular and Endovascular Surgery, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.
Patrick F WalkerDepartment of Surgery, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA.
Jonathan J MorrisonDivision of Vascular and Endovascular Surgery, Mayo Clinic, 200 1 Street, Rochester, MN 55905, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute mesenteric ischemia (AMI) is a surgical emergency requiring prompt revascularization with resection of unsalvageable bowel. Despite successful revascularization, ongoing organ damage can persist from ischemia-reperfusion injury (IRI) and there is a need for adjunct therapies to ameliorate this ongoing insult. Materials and methods: Sprague-Dawley rats ( Results: Twenty-three of 36 rats survived 4 h of reperfusion and there was no difference in survival between the groups. I-FABP levels was significantly lower in HEP+VER vs. control (3.8 ± 1.5 vs. 6.18 ± 1.0ng/ml; Conclusion: Administering heparin and verapamil at the time of revascularization may mitigate intestinal IRI without causing detrimental systemic effects. Further studies in large animal models and in the setting of local administration are needed to investigate the potential of this approach.

Indexed as

Acute mesenteric ischemiaAdjunct drug therapyHeparinIntestinal injuryIschemia-reperfusion injuryValproic acidVerapamil

Identifiers

PMID40534906
PMCPMC12175733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.