Evidence map›Paper›PMID 40534863›Full record

ArticleFrontiers in immunology2025

Role of CD28

Wuhan Yang, Teng Pan, Yaowen Chen, Hao Guo, Yaqi Peng, Chao Wang, Li Peng, Shubin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wuhan YangDepartment of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Teng PanDepartment of Oncology, Shijiazhuang First Hospital, Shijiazhuang, China.
Yaowen ChenDepartment of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Hao GuoDepartment of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yaqi PengDepartment of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Chao WangDepartment of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Li PengDepartment of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Shubin WangDepartment of General Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: CD28 Methods: We established a single-cell HCC transcriptional map, focusing on cell-cell communication and trajectory analysis of CD28 Results: Overall, 25,644 T cells were identified from single-cell RNA sequencing data from 10 HCC samples and corresponding normal samples. Overall T-cell infiltration was lower in HCC tissues, with significantly higher CD28 Conclusions: Significantly high CD28

Indexed as

Carcinoma, HepatocellularCD28 AntigensCD8-Positive T-LymphocytesLiver NeoplasmsLymphocytes, Tumor-InfiltratingProgrammed Cell Death 1 ReceptorBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisSingle-Cell AnalysisTumor MicroenvironmentBiomarkers, TumorCD28 AntigensPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCD28hepatocellular carcinomaPD-1single-cell RNA-seqt cell exhaustiontumor microenvironment

Identifiers

PMID40534863
PMCPMC12174045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.