Observational studyInternational journal of chronic obstructive pulmonary disease2025
Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice.
Observational study in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Dynamic frailty trajectories and risk of chronic obstructive pulmonary disease: a large-scale prospective cohort study.BMC pulmonary medicine · 2026Article
- Five-year changes in generic and disease-specific patient-reported outcome measures in stable COPD: a real-world cohort study.Patient related outcome measures · 2026Article
- Heterogeneous frailty trajectories and their differential impact on social integration in older adults with COPD: a prospective longitudinal study.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Although a cross-sectional association between frailty and chronic obstructive pulmonary disease (COPD) has been established, the longitudinal relationship between the progression of both frailty and COPD remains unclear. Materials and Methods: This longitudinal study followed 87 COPD patients over five years, with evaluations conducted every six months. Participants underwent pulmonary function tests and completed the Kihon Checklist, a tool widely used in Japan to assess frailty. Kihon Checklist scores range from 0 (no frailty) to 25 (severe frailty), categorizing participants as robust (0-3), pre-frail (4-7), or frail (8-25). Annual changes were analyzed using linear mixed models. Results: A significant association was observed between time and worsening frailty classification, with patients transitioning from robust to pre-frail or from pre-frail to frail (odds ratio: 1.224, Conclusion: COPD patients with frailty show a more rapid decline in FEV
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Registered trials
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