Evidence map›Paper›PMID 40534742›Full record

ArticleFrontiers in neurology2025

Pain- and depression-related regional homogeneity changes in ankylosing spondylitis: a functional magnetic resonance imaging study.

Kelei Hua, Peijun Wang, Bin Xia, Haiying Wang, Tianyue Wang, Jin Fang, Yi Yin, Yike Tu, Guihua Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelei Hua *Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Peijun Wang *Department of Medical Imaging, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China.
Bin Xia *Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Haiying WangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Tianyue WangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Jin FangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yi YinDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yike TuDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Guihua JiangDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Because of their ongoing pain, patients with ankylosing spondylitis (AS) are more likely to experience depression. Effective treatment remains a challenge. Additionally, the mechanisms of and relationships between AS-related pain and depression are inadequately understood. This study explored the regional homogeneity (ReHo) alterations linked to pain and depression in patients with AS. Methods: In total, 43 patients with AS (40 men, 3 women) and 46 controls who were matched by age and sex were recruited. The patients were clinically assessed based on Bath Ankylosing Spondylitis Disease Activity Index, the Total Back Pain (TBP) and Hamilton Rating Scale for Depression (HAMD) scores, erythrocyte sedimentation rate, and high-sensitivity C-reactive protein level. The ReHo differences based on 3-T magnetic resonance imaging were compared between patients with and without AS. Associations between significant variables and pain and depression were further explored. Results: Patients with AS had decreased ReHo values within the left superior temporal gyrus and right paracentral lobule and increased values within the left precuneus and right middle frontal gyrus compared to healthy controls ( Conclusion: This work provides fresh understanding of the brain processes behind depression and pain associated with AS. Stratifying patients based on features with significant correlations with pain and depression could help identify those at risk and thus apply individualized treatment.

Indexed as

ankylosing spondylitisdepressionfMRIpainregional homogeneity

Identifiers

PMID40534742
PMCPMC12173909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.