Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer.

Jie Li, Xinyan Pan, Yanting Bi, Jian Huang, Jun Peng, ChunLing Bai, Jianhong Hou, Yang Chen

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

A complete human pancreatic cancer genome.bioRxiv : the preprint server for biology · 2026
Article

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5 · Who and what money

Authors and funding

8 authors.

Jie Li *Academy of Biomedical Engineering, Kunming Medical University, Kunming, China.

Xinyan Pan *Department of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.

Yanting Bi *Academy of Biomedical Engineering, Kunming Medical University, Kunming, China.

Jian HuangDepartment of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.

Jun PengDepartment of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.

ChunLing BaiHuman Resources Office, Kunming Medical University, Kunming, China.

Jianhong HouDepartment of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.

Yang ChenDepartment of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC). Methods: Multi-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data, and cell-line drug sensitivity from TCGA and CCLE are delved into TDP characteristics. Results: Our thorough analysis reveals that patients with smaller span sizes TDP have a more intricate genome, moderate pathology, enhanced therapeutic response, favorable prognosis, a more active immune system, and higher drug sensitivity. In contrast, those with larger span sizes TDP exhibited opposite trends. Discussion: The integrated analysis underscores that an in-depth molecular assessment of TDP can offer invaluable insights into its role in cancers. Classification strategy of TDP could recognize the chemotherapy sensitivity of different NSCLC patients.

Indexed as

chemotherapyclinical pathologycopy number variancenon-small cell lung cancertandem duplicator phenotype

Identifiers

PMID40534701

DOI10.3389/fmed.2025.1556840

PMCPMC12174438

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