ArticleFrontiers in medicine2025
Differential target of oxidative damage in
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of autoimmune gastritis in gastric cancer risk: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Rethinking Oxidative Stress inLife (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oxidative stress, which characterizes inflammatory and autoimmune diseases, is involved in atrophic gastritis progression. We aimed to compare the presence and patterns of oxidative stress in autoimmune atrophic gastritis (AAG) and multifocal atrophic gastritis (MAG), investigating its role in disease progression and the development of genomic damage. Materials and methods: In this study, 120 consecutive patients with atrophic gastritis (70 AAG and 50 MAG) were collected. Serum/plasma dynamic reactive oxygen metabolites (dROM test-spectrophotometry), nitric oxide (NO-ELISA), advanced oxidation protein products (AOPPs-spectrophotometry), tissue levels of cytokines (IL-10 and TNFα-ELISA), and 8-hydroxydeoxyguanosine (8-OHdG) (HPLC-ED) were evaluated. Results: No significant differences in dROMs, NO, and AOPP levels were demonstrated between AAG and MAG. In AAG patients, those with early atrophy exhibited higher levels of dROMs compared to those with advanced stages ( Conclusion: Inflammatory responses and oxidative stress characterize atrophic gastritis, irrespective of etiology. However, a boost in inflammation-induced genomic damage is observed only in MAG, since AAG showed significantly lower 8-OHdG levels. Therefore, oxidative stress seem to play a minor role in the development of carcinoid and gastric cancer in AAG, and this finding may explain the lower risk of tumors in these patients.
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