ArticleFrontiers in medicine2025
Systemic inflammatory markers and neurovascular changes in the retina and choroid of diabetic patients without retinopathy: insights from wide-field SS-OCTA.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The retina-body axis: proteomic mechanisms linking oculomics and clinical traits in a female aging cohort.npj aging · 2026Article
- Monitoring Systemic Inflammatory Indices and Retinal Changes Over Time Following Initial Diagnosis of Diabetic Retinopathy.Journal of ophthalmology · 2026Article
- A panoramic perspective: application prospects and outlook of multimodal artificial intelligence in the management of diabetic retinopathy.Frontiers in public health · 2025Review
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6 authors.
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Abstract
Purpose: The purpose of this study was to investigate the association between systemic inflammation markers and early neuronal and microvascular changes in the retinal and choroidal regions of patients with type 2 diabetes mellitus (T2DM) without clinical signs of diabetic retinopathy (DR), utilizing wide-field swept-source optical coherence tomography angiography (SS-OCTA). Methods: This retrospective, observational cohort study included 61 patients (119 eyes) with T2DM without clinical DR (NDR group) and 44 healthy individuals (82 eyes) as controls. All participants underwent a comprehensive ophthalmic evaluation and blood sampling for hematologic indices. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), were calculated. The mean thickness of the retina, choroid, and individual inner retinal layers, as well as the vessel density measurements of the superficial and deep retinal layers, and the choriocapillaris perfusion area, were recorded and analyzed from the OCTA images. Additionally, the choroidal vascularity index (CVI) was determined. Results: The NDR group demonstrated significantly higher levels of NLR, SII, and SIRI compared to the control group ( Conclusion: The study provides new insights into the role of systemic inflammation in early structural and blood flow changes in the retina and choroid, occurring prior to the onset of DR. The findings highlight the importance of inflammation in the pathogenesis of DR, even in the absence of clinical signs, suggesting that systemic inflammatory markers may serve not only as early biomarkers of ocular changes in T2DM but also as potential early therapeutic targets to prevent or delay diabetic retinopathy.
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