Evidence map›Paper›PMID 40534646›Full record

ArticleJournal of multidisciplinary healthcare2025

Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 Patients During the First Wave of Pandemic.

Hossam Gad, Mohamed A Mahmoud, Mohamed Antar, Ahmed Sayed Ahmed, Krzysztof Laudanski

Abstract read
In one paragraph

Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hossam Gad *Department of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.ORCID 0009-0001-1828-8167
Mohamed A Mahmoud *Division Pulmonary and Critical Care, Mayo Clinic, Rochester, MN, USA.
Mohamed AntarDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.ORCID 0009-0000-6647-9278
Ahmed Sayed AhmedDivision Pulmonary and Critical Care, Mayo Clinic, Rochester, MN, USA.
Krzysztof LaudanskiDepartment of Anesthesiology and Critical care, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7373-0851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Recent discoveries have pointed to the role of IGFALS immunological response to viral challenges, potentially leading to the emergence of a cytokine storm. Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence. Patients and Methods: We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (t Results: No difference between serum IGFALS and IGF-1 levels was seen across the studied time points. IGFALS Conclusion: Though IGFALS serum levels did not change significantly during SARS-CoV-2 infection, we observed correlations with markers of tissue destruction, C-reactive protein, IL-6, and length of hospital stay.

Indexed as

COVID-19cytokine stormIGFALSIL-6infectionlongitudinal studySARS-CoV-2

Identifiers

PMID40534646
PMCPMC12176063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.