ArticleAmerican journal of preventive cardiology2025
Coronary inflammation and atherosclerosis by CCTA in young adults (aged 18-45).
Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials.Journal of the American College of Cardiology · 2026Trial
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18 authors.
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Abstract
Background: Peri-coronary adipose tissue attenuation (PCAT), a marker of coronary inflammation, is linked to coronary artery disease (CAD), but data on the role of PCAT in young individuals are limited. Aims: This study explores the interplay of PCAT and CAD by CCTA, in a symptomatic young cohort. Methods and Results: Patients aged 18-45 years without prior CAD, from Montefiore CCTA registry (2016-2022), were studied retrospectively. Atherosclerosis and PCAT of the left circumflex (LCX), left anterior descending (LAD), and right coronary artery (RCA) were measured. Youden index determined optimal PCAT thresholds for the risk of CAD, defined as presence of any coronary plaque. Multivariable logistic regression analyses assessed the relationship between PCAT and CAD. The study included 733 consecutive patients (37±5 years, 55 % women, 44 % Hispanic, 23 % non-Hispanic Black); 15 % had CAD. Patients with CAD had higher overall PCAT (-77.5 HU vs -79.5, Conclusion: Coronary inflammation is associated with CAD in young patients, independently of traditional risk factors, even among patients with CAC=0 score. These findings highlight its potential as an early marker for guiding preventive strategies.
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